Pathophysiology remains poorly understood; hormone alteration plays a central role — cellular accumulation of testosterone, particularly the active metabolite dihydrotestosterone DHT.
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Almost exclusively involves the area of transition zone TZ. Presents with lower urinary tract symptoms LUTS. Most common non-cancerous cause of serum PSA elevation. Hallmark is nodular prostatic enlargement.
Hyperplastic nodules are often multiple, mainly centered on proximal prostatic urethra involving submucosal compartment and TZ Microscopic histologic description Hyperplasia of glandular and stromal tissue with papillary buds, infoldings and cysts Associated with squamous metaplasia and infarction Begins around urethra Gay places in Sweeden Nynashamn ejaculatory ducts Mottala prostate transitional or periurethral zone Basal cell layer is continuous Stromal changes are increased smooth muscle, lymphocytes and ducts not associated with infectious process of prostatitis in most casesreduced elastic tissue Variations include sclerosing adenosis, fibroadenoma-like and phyllodes-like hyperplasia, leiomyoma-like nodules, fibromyxoid nodules; associated with infarct.
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